Working internally, systemic treatments may be taken orally, as in a pill or injected into the skin. Systemic treatments are used in the case of moderate acne, when topical treatments aren't enough, as well as for severe and cystic acne. Systemic treatments are available by prescription only and are often used in conjunction with topical treatments. Systemic acne treatments include oral antibiotics, hormonal treatments, and isotretinoin (sold in brand names such as Accutane).
c) Oral antibiotics
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